Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.

doi:10.1038/s41467-024-48269-2

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Article

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.

Nature communications - 16 May 2024

Mistretta Maxime, Cimino Mena, Campagne Pascal, Volant Stevenn, Kornobis Etienne, Hebert Olivier, Rochais Christophe, Dallemagne Patrick, Lecoutey Cédric, Tisnerat Camille, Lepailleur Alban, Ayotte Yann, LaPlante Steven R, Gangneux Nicolas, Záhorszká Monika, Korduláková Jana, Vichier-Guerre Sophie, Bonhomme Frédéric, Pokorny Laura, Albert Marvin, Tinevez Jean-Yves, Manina Giulia

Abstract excerpt

Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis of individual cells that is technically challenging, and hard to integrate into drug discovery. In this work, we develop a multi-condition microfluidic platform suitable for...

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PMID: 38755132
DOI: 10.1038/s41467-024-48269-2
PMCID: PMC11099131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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