Article
The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice.
Acta neuropathologica communications - 18 Nov 2013
Rijal Upadhaya Ajeet, Scheibe Frederik, Kosterin Irina, Abramowski Dorothee, Gerth Janina, Kumar Sathish, Liebau Stefan, Yamaguchi Haruyasu, Walter Jochen, Staufenbiel Matthias, Thal Dietmar Rudolf
Abstract excerpt
BACKGROUND: The deposition of the amyloid β-peptide (Aβ) in the brain is one of the hallmarks of Alzheimer's disease (AD). It is not yet clear whether Aβ always leads to similar changes or whether it induces different features of neurodegeneration in relation to its intra- and/or extracellular localization or to its intracellular trafficking routes. To address this question, we have analyzed two transgenic mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.