Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study.

doi:10.1186/s12891-015-0678-z

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Article

Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study.

BMC musculoskeletal disorders - 21 Aug 2015

Fernández-Torres Javier, Hernández-Díaz Cristina, Espinosa-Morales Rolando, Camacho-Galindo Javier, Galindo-Sevilla Norma del Carmen, López-Macay Ámbar, Zamudio-Cuevas Yessica, Martínez-Flores Karina, Santamaría-Olmedo Mónica Guadalupe, Pineda Carlos, Granados Julio, Martínez-Nava Gabriela Angélica, Gutiérrez Marwin, López-Reyes Alberto G

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a multifactorial degenerative condition of the whole joint with a complex pathogenesis whose development and progression is significantly mediated by interactions between the joint cartilage and articular tissues, particularly, proinflammatory mediators and oxidative stress, which results in cartilage deterioration and subchondral bone destruction. HIF-1 alpha regulates oxygen...

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PMID: 26293784
DOI: 10.1186/s12891-015-0678-z
PMCID: PMC4546180

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