A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis.

doi:10.1002/jor.22063

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Article

A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2012

Nakajima Masahiro, Shi Dongquan, Dai Jin, Tsezou Aspasia, Zheng Minghao, Norman Paul E, Chou Ching-Heng, Lee Ming Ta Michael, Hwang Joo-Yeon, Kim Dong-Hyun, Takahashi Atsushi, Ikegawa Shiro, Jiang Qing

Abstract excerpt

Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2α with knee OA has been reported in a Japanese population; however, controversy exits for its replication and a role of HIF-2α in OA. This study aimed to evaluate the association of the SNP by a large-scale replication study. A total of...

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PMID: 22247019
DOI: 10.1002/jor.22063

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