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Article

Infectious diseases, IL6 -174G>C polymorphism, and human development.

Brain, behavior, and immunity - 1 Jan 2016

Napolioni Valerio, MacMurray James

Abstract excerpt

Interleukin-6 (IL6) is a pro-inflammatory cytokine that is required for resistance against many pathogens. However, sustained IL6 activity can cause tissue damage in the periphery and brain. Previous studies have shown that populations in disease-endemic regions adapt by selecting the high-producing G-allele at the -174G>C (rs1800795) polymorphism, while others have linked increased IL6 to cognitive impairments....

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Identifiers

PMID: 26291404
DOI: 10.1016/j.bbi.2015.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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