Article
Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.
Journal of human genetics - 1 Nov 2015
Miyadera Hiroko, Tokunaga Katsushi
Abstract excerpt
The mechanism of genetic associations between human leukocyte antigen (HLA) and susceptibility to autoimmune disorders has remained elusive for most of the diseases, including rheumatoid arthritis (RA) and type 1 diabetes (T1D), for which both the genetic associations and pathogenic mechanisms have been extensively analyzed. In this review, we summarize what are currently known about the mechanisms of HLA...
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