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Article

Genetic background of tolerance breakdown in rheumatoid arthritis.

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology - 1 Jan 2010

Kochi Yuta

Abstract excerpt

Rheumatoid arthritis (RA) is a complex mutifactorial autoimmune disease. As anti-citrullinated peptide antibodies (ACPA) exhibit unique specificity for RA, breakdown of immunological tolerance to citrullinated self-proteins is considered to be a key feature of RA pathogenesis. While environmental factors such as smoking and viral infections have been implicated in the pathogenesis, recent genome-scans for RA have...

Read the complete abstract on PubMed

Topics

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Protein-Arginine Deiminase Type 4

Share to Protein-Arginine Deiminases

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptors, Immunologic

Source

Identifiers

PMID: 20453439
DOI: 10.2177/jsci.33.48

Genes

FCRL3
PADI4
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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