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Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

13 Mar 2025

Abstract excerpt

Mitochondria‑derived peptides (MDPs) are a unique class of peptides encoded by short open reading frames in mitochondrial DNA, including the mitochondrial open reading frame of the 12S ribosomal RNA type‑c (MOTS‑c). Recent studies suggest that MDPs offer therapeutic benefits in various diseases, including neurodegenerative disorders and types of cancer, due to their ability to increase cellular resilience....

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PMID: 40084698
DOI: 10.3892/mmr.2025.13492

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