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Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6

29 Aug 2023

Abstract excerpt

Mitochondrial-derived peptides are encoded by mitochondrial DNA but have biological activity outside mitochondria. Eight of these are encoded by sequences within the mitochondrial 12S and 16S ribosomal genes: humanin, MOTS-c, and the six SHLP peptides, SHLP1-SHLP6. These peptides have various effects in cell culture and animal models, affecting neuroprotection, insulin sensitivity, and apoptosis, and some are...

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PMID: 37644144
DOI: 10.1038/s41598-023-41053-0

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