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Article

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.

The Journal of antimicrobial chemotherapy - 1 Sept 2011

Wyen Christoph, Hendra Heidy, Siccardi Marco, Platten Martin, Jaeger Hans, Harrer Thomas, Esser Stefan, Bogner Johannes R, Brockmeyer Norbert H, Bieniek Bernhard, Rockstroh Juergen, Hoffmann Christian, Stoehr Albrecht, Michalik Claudia, Dlugay Verena, Jetter Alexander, Knechten Heribert, Klinker Hartwig, Skaletz-Rorowski Adriane, Fätkenheuer Gerd, Egan Deirdre, Back David J, Owen Andrew

Abstract excerpt

OBJECTIVES: Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenz pharmacokinetics. Since the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) correlate with CYP2B6 in liver, and a CAR polymorphism (rs2307424) and smoking correlate with efavirenz plasma concentrations,...

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Source

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PMID: 21715435
DOI: 10.1093/jac/dkr272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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