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Article

Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Feb 2006

Ribaudo Heather J, Haas David W, Tierney Camlin, Kim Richard B, Wilkinson Grant R, Gulick Roy M, Clifford David B, Marzolini Catia, Fletcher Courtney V, Tashima Karen T, Kuritzkes Daniel R, Acosta Edward P

Abstract excerpt

BACKGROUND: Efavirenz has a long plasma half-life and a low genetic barrier to resistance. Simultaneously stopping treatment with all agents in efavirenz-containing regimens may result in functional efavirenz monotherapy that selects for drug-resistant human immunodeficiency virus type 1. Lower plasma efavirenz clearance is associated with a cytochrome P450 2B6 gene (CYP2B6) polymorphism (516G-->T) that is more...

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PMID: 16392089
DOI: 10.1086/499364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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