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Article

Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 during H. capsulatum infection.

Molecular microbiology - 1 Dec 2015

Isaac Dervla T, Berkes Charlotte A, English Bevin C, Murray Davina Hocking, Lee Young Nam, Coady Alison, Sil Anita

Abstract excerpt

Microbial pathogens induce or inhibit death of host cells during infection, with significant consequences for virulence and disease progression. Death of an infected host cell can either facilitate release and dissemination of intracellular pathogens or promote pathogen clearance. Histoplasma capsulatum is an intracellular fungal pathogen that replicates robustly within macrophages and triggers macrophage lysis...

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Identifiers

PMID: 26288377
DOI: 10.1111/mmi.13168
PMCID: PMC5002445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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