Article
Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI.
Cytoskeleton (Hoboken, N.J.) - 1 Sept 2015
Hegan Peter S, Kravtsov Dmitri V, Caputo Christina, Egan Marie E, Ameen Nadia A, Mooseker Mark S
Abstract excerpt
Myosin Ia (Myo1a), the most prominent plus-end directed motor and myosin VI (Myo6) the sole minus-end directed motor, together exert opposing tension between the microvillar (MV) actin core and the apical brush border (BB) membrane of the intestinal epithelial cell (IEC). Mice lacking Myo1a or Myo6 each exhibit a variety of defects in the tethering of the BB membrane to the actin cytoskeleton. Double mutant (DM)...
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