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Article

Concerted actions of distinct nonmuscle myosin II isoforms drive intracellular membrane remodeling in live animals.

The Journal of cell biology - 3 Jul 2017

Milberg Oleg, Shitara Akiko, Ebrahim Seham, Masedunskas Andrius, Tora Muhibullah, Tran Duy T, Chen Yun, Conti Mary Anne, Adelstein Robert S, Ten Hagen Kelly G, Weigert Roberto

Abstract excerpt

Membrane remodeling plays a fundamental role during a variety of biological events. However, the dynamics and the molecular mechanisms regulating this process within cells in mammalian tissues in situ remain largely unknown. In this study, we use intravital subcellular microscopy in live mice to study the role of the actomyosin cytoskeleton in driving the remodeling of membranes of large secretory granules, which...

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Identifiers

PMID: 28600434
DOI: 10.1083/jcb.201612126
PMCID: PMC5496622

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