Article
Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2015
Abdolmaleky Hamid M, Pajouhanfar Sara, Faghankhani Masoomeh, Joghataei Mohammad Taghi, Mostafavi Ashraf, Thiagalingam Sam
Abstract excerpt
Due to the lack of genetic association between individual genes and schizophrenia (SCZ) pathogenesis, the current consensus is to consider both genetic and epigenetic alterations. Here, we report the examination of DNA methylation status of DTNBP1 promoter region, one of the most credible candidate genes affected in SCZ, assayed in saliva and post-mortem brain samples. The Illumina DNA methylation profiling and...
Topics
- Antipsychotic Agents
- Base Sequence
- Bipolar Disorder
- Brain Chemistry
- Case-Control Studies
- CpG Islands
- DNA
- DNA Methylation
- Dysbindin