DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.

doi:10.1016/j.jpsychires.2011.06.013

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Article

DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.

Journal of psychiatric research - 1 Nov 2011

Nohesara Shabnam, Ghadirivasfi Mohammad, Mostafavi Sahar, Eskandari Mohammad-Reza, Ahmadkhaniha HamidReza, Thiagalingam Sam, Abdolmaleky Hamid Mostafavi

Abstract excerpt

The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 115 human post-mortem brain samples from the frontal lobe and reported DNA hypo methylation of the...

Topics

Adult
Bipolar Disorder
Case-Control Studies
Catechol O-Methyltransferase
DNA Methylation
Epigenomics
Family
Female
Gene Expression
Genetic Predisposition to Disease
Humans
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Promoter Regions, Genetic

Risk Factors

Saliva

Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 21820670
DOI: 10.1016/j.jpsychires.2011.06.013

Genes

COMT
MB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.