Article
Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men.
Journal of epidemiology - 5 Apr 2018
Sasakabe Tae, Wakai Kenji, Kawai Sayo, Hishida Asahi, Naito Mariko, Suzuki Sadao, Nindita Yora, Arisawa Kokichi, Kita Yoshikuni, Hara Megumi, Kuriyama Nagato, Hirata Akie, Mikami Haruo, Oze Isao, Kubo Michiaki, Tanaka Hideo, Hamajima Nobuyuki
Abstract excerpt
BACKGROUND: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be...
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