ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men.

doi:10.1210/clinem/dgab324

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ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men.

The Journal of clinical endocrinology and metabolism - 18 Aug 2021

Takeno Kageumi, Tamura Yoshifumi, Kakehi Saori, Kaga Hideyoshi, Kawamori Ryuzo, Watada Hirotaka

Abstract excerpt

CONTEXT: A recent meta-analysis of genome-wide association studies data from East Asians identified aldehyde dehydrogenase 2 (ALDH2) rs671 as a susceptibility variant for type 2 diabetes in males. OBJECTIVE: To investigate the association between ALDH2 rs671 and metabolic characteristics. METHODS: We studied 94 nonobese, nondiabetic, Japanese men. Using a 2-step hyperinsulinemic-euglycemic clamp, we evaluated...

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Adiposity
Alcohol Drinking

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aldehyde Dehydrogenase, Mitochondrial

Blood Glucose

Glucose Clamp Technique

Insulin Resistance

Lipid Metabolism

Magnetic Resonance Spectroscopy

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Open in PubMed

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PMID: 33974068
DOI: 10.1210/clinem/dgab324

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