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Article

Definition of the cattle killer cell Ig-like receptor gene family: comparison with aurochs and human counterparts.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Sanderson Nicholas D, Norman Paul J, Guethlein Lisbeth A, Ellis Shirley A, Williams Christina, Breen Matthew, Park Steven D E, Magee David A, Babrzadeh Farbod, Warry Andrew, Watson Mick, Bradley Daniel G, MacHugh David E, Parham Peter, Hammond John A

Abstract excerpt

Under selection pressure from pathogens, variable NK cell receptors that recognize polymorphic MHC class I evolved convergently in different species of placental mammal. Unexpectedly, diversified killer cell Ig-like receptors (KIRs) are shared by simian primates, including humans, and cattle, but not by other species. Whereas much is known of human KIR genetics and genomics, knowledge of cattle KIR is limited to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25398326
DOI: 10.4049/jimmunol.1401980
PMCID: PMC4258407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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