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Article

Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2015

Keil Kimberly P, Altmann Helene M, Abler Lisa L, Hernandez Laura L, Vezina Chad M

Abstract excerpt

BACKGROUND: Epigenetic factors influence stem cell function and other developmental events but their role in prostate morphogenesis is not completely known. We tested the hypothesis that histone deacetylase (HDAC) activity is required for prostate morphogenesis. RESULTS: We identified the presence of class I nuclear HDACs in the mouse urogenital sinus (UGS) during prostate development and found that Hdac 2 mRNA...

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Identifiers

PMID: 26283270
DOI: 10.1002/dvdy.24321
PMCID: PMC4619142

Genes

SMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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