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Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

18 Aug 2015

Abstract excerpt

The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans with an approximately 30% mortality rate. The envelope spike glycoprotein on the surface of MERS-CoV mediates receptor binding, membrane fusion, and viral entry. We previously reported two human monoclonal antibodies that target the receptor binding domain (RBD) of the spike and exhibit strong...

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PMID: 26281793
DOI: 10.1038/srep13133

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