Article
Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein.
Virus research - 1 Mar 2020
Goo Junghyun, Jeong Yuji, Park Young-Shin, Yang Eunji, Jung Dae-Im, Rho Semi, Park Uni, Sung Hyeyeong, Park Pil-Gu, Choi Jung-Ah, Seo Sang Hwan, Cho Nam Hyuck, Lee Hyeja, Lee Jae Myun, Kim Jae-Ouk, Song Manki
Abstract excerpt
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe pulmonary infection, with ∼35 % mortality. Spike glycoprotein (S) of MERS-CoV is a key target for vaccines and therapeutics because S mediates viral entry and membrane-fusion to host cells. Here, four different S subunit proteins, receptor-binding domain (RBD; 358-606 aa), S1 (1-751 aa), S2 (752-1296 aa), and SΔTM (1-1296 aa), were generated...
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