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Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

28 Sept 2022

Abstract excerpt

Neutralizing monoclonal antibodies (mAbs) against highly pathogenic coronaviruses represent promising candidates for clinical intervention. Here, we isolated a potent neutralizing monoclonal antibody, MERS-S41, from a yeast displayed scFv library using the S protein as a bait. To uncover the neutralization mechanism, we determined structures of MERS-S41 Fab in complex with the trimeric spike glycoprotein by...

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Share to Bacteriophages and microbial interactions
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PMID: 36246239
DOI: 10.3389/fmicb.2022.988298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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