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Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

11 Jul 2019

Abstract excerpt

Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). The epitopes and mechanisms of mAbs targeting non-RBD regions have not been well characterized yet. Here we report the monoclonal antibody 7D10 that binds to the N-terminal...

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PMID: 31296843
DOI: 10.1038/s41467-019-10897-4

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