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Article

Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity.

Obesity (Silver Spring, Md.) - 1 Sept 2013

Carpenter Catherine L, Wong Angela M, Li Zhaoping, Noble Ernest P, Heber David

Abstract excerpt

OBJECTIVE: The brain reward circuits that promote drug abuse may also be involved in pleasure seeking behavior and food cravings observed in severely obese subjects. Drug addiction polymorphisms such as the TaqI A1 allele of the dopamine D2 receptor (DRD2) are associated with cocaine, alcohol, and opioid use, but few studies have linked DRD2 to food craving. Other genes such as the leptin receptor gene (LEPR) and...

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Source

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Identifiers

PMID: 23670889
DOI: 10.1002/oby.20202
PMCID: PMC7081169

Genes

DRD2
LEPR
OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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