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Article

Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta.

Bone - 1 Dec 2015

Abdelaziz Dareen M, Abdullah Sami, Magnussen Claire, Ribeiro-da-Silva Alfredo, Komarova Svetlana V, Rauch Frank, Stone Laura S

Abstract excerpt

Osteogenesis imperfecta (OI) is a congenital disorder caused most often by dominant mutations in the COL1A1 or COL1A2 genes that encode the alpha chains of type I collagen. Severe forms of OI are associated with skeletal deformities and frequent fractures. Skeletal pain can occur acutely after fracture, but also arises chronically without preceding fractures. In this study we assessed OI-associated pain in the...

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Source

Identifiers

PMID: 26277094
DOI: 10.1016/j.bone.2015.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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