Article
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.
Bone - 1 Feb 2010
Jimenez-Andrade Juan Miguel, Mantyh William G, Bloom Aaron P, Xu Haili, Ferng Alice S, Dussor Gregory, Vanderah Todd W, Mantyh Patrick W
Abstract excerpt
Although musculoskeletal pain is one of the most common causes of chronic pain and physical disability in both developing and developed countries, relatively little is known about the nerve fibers and mechanisms that drive skeletal pain. Small diameter sensory nerve fibers, most of which are C-fiber nociceptors, can be separated into two broad populations: the peptide-rich and peptide-poor nerve fibers....
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