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Article

Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome.

Pain - 1 Oct 2020

Syx Delfien, Miller Rachel E, Obeidat Alia M, Tran Phuong B, Vroman Robin, Malfait Zoë, Miller Richard J, Malfait Fransiska, Malfait Anne-Marie

Abstract excerpt

Classical Ehlers-Danlos syndrome (cEDS) is a connective tissue disorder caused by heterozygous mutations in one of the type V collagen-encoding genes, COL5A1 or COL5A2. cEDS is characterized by generalized joint hypermobility and instability, hyperextensible, fragile skin, and delayed wound healing. Chronic pain is a major problem in cEDS patients, but the underlying mechanisms are largely unknown, and studies in...

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Identifiers

PMID: 32483055
DOI: 10.1097/j.pain.0000000000001935
PMCID: PMC7967806

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