Article
BRAF, KIT, NRAS, GNAQ and GNA11 mutation analysis in cutaneous melanomas in Turkish population.
Indian journal of pathology & microbiology - 1 Jan 2000
Yilmaz Ismail, Gamsizkan Mehmet, Kucukodaci Zafer, Berber Ufuk, Demirel Dilaver, Haholu Aptullah, Narli Gizem
Abstract excerpt
BACKGROUND: KIT and mitogen-activated protein kinase cascade are important for melanomagenesis. In the present study, we analyzed the frequency of BRAF, NRAS, KIT, GNAQ and GNA11 gene mutations and investigated their association with clinicopathological features of melanomas in Turkish population. MATERIALS AND METHODS: Forty-seven primary cutaneous melanomas were included in our study. Sanger sequencing method...
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