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Article

The frequency and clinicopathological significance of NRAS mutations in primary cutaneous nodular melanoma in Indonesia.

Cancer reports (Hoboken, N.J.) - 1 Jan 2022

Rinonce Hanggoro Tri, Sastri Deflen Jumatul, Trisnawati Fita, Kameswari Bidari, Ferronika Paranita, Irianiwati

Abstract excerpt

BACKGROUND: Melanoma is a lethal skin malignancy with a high risk of metastasis, which prompts a need for research on treatment targets and prognostic factors. Recent studies show that the presence of neuroblastoma RAS viral oncogene homolog (NRAS) mutation can influence cell growth in melanomas. The NRAS mutation, which stimulates the mitogen-activated protein kinase (MAPK) signaling pathway, is associated with...

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Identifiers

PMID: 34110110
DOI: 10.1002/cnr2.1454
PMCID: PMC8789608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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