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Article

BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.

Investigative ophthalmology & visual science - 1 Jan 2018

Francis Jasmine H, Grossniklaus Hans E, Habib Larissa A, Marr Brian, Abramson David H, Busam Klaus J

Abstract excerpt

Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all blue nevi, a...

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Topics

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Share to Conjunctiva
Share to DNA, Neoplasm
Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Immunohistochemistry

Share to Nevus, Pigmented

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29332123
DOI: 10.1167/iovs.17-22517
PMCID: PMC6110167

Genes

NRAS
BRAF
GNAQ

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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