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Article

Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome.

Journal of translational medicine - 14 Aug 2015

Löbel Madlen, Mooslechner Agnes Anna, Bauer Sandra, Günther Sabrina, Letsch Anne, Hanitsch Leif G, Grabowski Patricia, Meisel Christian, Volk Hans-Dieter, Scheibenbogen Carmen

Abstract excerpt

BACKGROUND: Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an increased sensitivity to pain and sensory stimuli. A subset of patients has frequent respiratory tract infections (RRTI). Dysregulation of the sympathetic nervous system and an association with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26272340
DOI: 10.1186/s12967-015-0628-4
PMCID: PMC4536662

Genes

COMT
CRHR1
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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