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Article

Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients.

Life sciences - 27 Feb 2013

Fukuda Sanae, Horiguchi Mieko, Yamaguti Kouzi, Nakatomi Yasuhito, Kuratsune Hirohiko, Ichinose Hiroshi, Watanabe Yasuyoshi

Abstract excerpt

AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Since catecholamines and BH4 are thought to be involved in the pathophysiology of CFS, we explored the genetic factors that influence CFS development and examined the possible association between the SNPs of the TH and GCH genes and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23246742
DOI: 10.1016/j.lfs.2012.11.016

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