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Article

Loss of N-linked glycosylation from the hemagglutinin-neuraminidase protein alters virulence of Newcastle disease virus.

Journal of virology - 1 May 2004

Panda Aruna, Elankumaran Subbiah, Krishnamurthy Sateesh, Huang Zhuhui, Samal Siba K

Abstract excerpt

The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is an important determinant of its virulence. We investigated the role of each of the four functional N-linked glycosylation sites (G1 to G4) of the HN glycoprotein of NDV on its pathogenicity. The N-linked glycosylation sites G1 to G4 at residues 119, 341, 433, and 481, respectively, of a moderately pathogenic NDV strain Beaudette C...

Topics

Antibodies, Monoclonal
Glycosylation
HN Protein
Mutation
Newcastle disease virus
Precipitin Tests
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15113876
DOI: 10.1128/jvi.78.10.4965-4975.2004
PMCID: PMC400364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15113876-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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