Identification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity.

doi:10.1186/s13567-021-01019-4

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Article

Identification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity.

Veterinary research - 20 Dec 2021

Chen Xi, Jia Yanqing, Wei Ning, Ye Chao, Hao Huafang, Xiao Sa, Wang Xinglong, Liu Haijin, Yang Zengqi

Abstract excerpt

The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are viral entry proteins and are recognized as the major virulence determinants. Previously, a lentogenic NDV virus (CE16) was derived from a mesogenic strain (CI10) through sequential passages in chick...

Topics

Amino Acids
Animals
Chick Embryo
Chickens
HN Protein
Mutation
Newcastle Disease
Newcastle disease virus
Virulence

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