A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.

doi:10.1210/jc.2015-2126

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Article

A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.

The Journal of clinical endocrinology and metabolism - 1 Oct 2015

Schunter Jo Ana, Löffler Dennis, Wiesner Tobias, Kovacs Peter, Badenhoop Klaus, Aust Gabriela, Tönjes Anke, Müller Peter, Baber Ronny, Simon Jan C, Führer Dagmar, Pfäffle Roland W, Thiery Joachim, Stumvoll Michael, Kiess Wieland, Kratzsch Jürgen, Körner Antje

Abstract excerpt

CONTEXT: Vitiligo frequently coincides with autoimmune endocrinopathies, particularly Hashimoto's thyroiditis (HT). Genetic susceptibility may underlie this coincident occurrence. One candidate region is the autoimmunity susceptibility locus on chromosome 1, which encompasses forkhead transcription factor D3 (FoxD3), a gene involved in embryonal melanogenesis. We identified a promotor variant (rs78645479) in an...

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PMID: 26267147
DOI: 10.1210/jc.2015-2126

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