Article
Association between FOXP3 polymorphisms and vitiligo in a Han Chinese population.
The British journal of dermatology - 1 Sept 2013
Song P, Wang X-W, Li H-X, Li K, Liu L, Wei C, Jian Z, Yi X-L, Li Q, Wang G, Li C-Y, Gao T-W
Abstract excerpt
BACKGROUND: Vitiligo is an autoimmune chronic depigmentation disorder caused by melanocyte loss. Previous studies found that CD4(+)CD25(+) regulatory T-cell (Treg) dysfunction was involved in the pathogenesis of vitiligo and that gene polymorphisms in forkhead box P3 (FOXP3) - a master regulator of Treg development and function - were associated with susceptibility to some autoimmune disorders. Therefore, we...
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