Article
The use of FNA samples for whole-exome sequencing and detection of somatic mutations in breast cancer surgical specimens.
Cancer cytopathology - 1 Nov 2015
Lee Han-Byoel, Joung Je-Gun, Kim Jisun, Lee Kyung-Min, Ryu Han Suk, Lee Hae-Ock, Moon Hyeong-Gon, Park Woong-Yang, Noh Dong-Young, Han Wonshik
Abstract excerpt
BACKGROUND: The availability of suitable biospecimens is critical to the success of advanced genomic analyses. The objective of this study was to assess the sensitivity of fine-needle aspiration (FNA) compared with gross surgical sampling (GSS) from surgical specimens for the detection of somatic mutations in breast cancer using whole-exome sequencing (WES). METHODS: DNA was extracted from paired GSS tissues and...
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