Article
No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy.
Clinical science (London, England : 1979) - 1 Dec 2006
Lieb Wolfgang, Bolbrinker Juliane, Döring Angela, Hense Hans-Werner, Erdmann Jeanette, Schunkert Heribert, Kreutz Reinhold
Abstract excerpt
A polymorphism in the cytochrome P450 3A CYP3A5 enzyme has been implicated in BP (blood pressure) control and arterial hypertension. Carriers of the CYP3A5*1 allele had high, whereas homozygous carriers of the CYP3A5*3 allele exhibit low, CYP3A5 expression in the kidney, where CYP3A5 represents the major CYP3A enzyme. The aim of the present study was to investigate the association of the CYP3A5*1 allele with BP,...
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