Article
Loss of Antibiotic Tolerance in Sod-Deficient Mutants Is Dependent on the Energy Source and Arginine Catabolism in Enterococci.
Journal of bacteriology - 1 Oct 2015
Ladjouzi Rabia, Bizzini Alain, van Schaik Willem, Zhang Xinglin, Rincé Alain, Benachour Abdellah, Hartke Axel
Abstract excerpt
UNLABELLED: Enterococci are naturally tolerant to typically bactericidal cell wall-active antibiotics, meaning that their growth is inhibited but they are not killed even when exposed to a high concentration of the drug. The molecular reasons for this extraordinary tolerance are still incompletely understood. Previous work showed that resistance to killing collapsed specifically in mutants affected in superoxide...
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