Article
Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.
Science (New York, N.Y.) - 12 Oct 2001
Eggert U S, Ruiz N, Falcone B V, Branstrom A A, Goldman R C, Silhavy T J, Kahne D
Abstract excerpt
Small molecules that affect specific protein functions can be valuable tools for dissecting complex cellular processes. Peptidoglycan synthesis and degradation is a process in bacteria that involves multiple enzymes under strict temporal and spatial regulation. We used a set of small molecules that inhibit the transglycosylation step of peptidoglycan synthesis to discover genes that help to regulate this process....
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