Article
Implication of (Mn)superoxide dismutase of Enterococcus faecalis in oxidative stress responses and survival inside macrophages.
Microbiology (Reading, England) - 1 Sept 2006
Verneuil Nicolas, Mazé Alain, Sanguinetti Maurizio, Laplace Jean-Marie, Benachour Abdellah, Auffray Yanick, Giard Jean-Christophe, Hartke Axel
Abstract excerpt
The gene encoding the manganese-containing superoxide dismutase (MnSOD) of Enterococcus faecalis was characterized. It is transcribed monocistronically from an upstream promoter identified by rapid amplification of cDNA ends (RACE)-PCR. A sodA mutant was constructed and characterized. Growth of the mutant strain was not significantly different from that of its wild-type counterpart in standing and aerated...
Topics
- Animals
- Enterococcus faecalis
- Genetic Complementation Test
- Kinetics
- Macrophages, Peritoneal
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Oxidative Stress
- Superoxide Dismutase
