Article
Genetic profiles and clinical features in subcutaneous panniculitis-like T-cell lymphomas.
Cancer science - 1 Nov 2024
Okamura Yui, Makishima Kenichi, Suehara Yasuhito, Suma Sakurako, Abe Yoshiaki, Matsuoka Ryota, Sakamoto Tatsuhiro, Hattori Keiichiro, Yokoyama Yasuhisa, Kato Takayasu, Nanmoku Toru, Iwasaki Takeshi, Nishiyama Kenichi, Kato Koji, Takeuchi Yasuhide, Makishima Hideki, Nakamura Naoya, Chiba Shigeru, Sakata-Yanagimoto Mamiko
Abstract excerpt
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare peripheral T-cell lymphoma characterized by cutaneous lesions and immunologic manifestations. The five-year survival rate of SPTCL has been reported to be over 80%, indicating a favorable prognosis. Recent studies have uncovered recurrent germline variants in HAVCR2, encoding an immunomodulator. In this study, we integrated whole-exome sequencing...
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