Article
Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2005
Kouriba Bourema, Chevillard Christophe, Bream Jay H, Argiro Laurent, Dessein Helia, Arnaud Violaine, Sangare Lansana, Dabo Abdoulaye, Beavogui Abdou Habib, Arama Charles, Traoré Hamar A, Doumbo Ogobara, Dessein Alain
Abstract excerpt
Millions of humans are exposed to schistosome infections, which cause severe kidney and liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human defenses against this pathogen and susceptibility to infection is controlled by a major genetic locus that includes IL4, IL5, and IL13 genes. These observations led us to evaluate whether certain polymorphisms in IL4, IL5, or IL13 determine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.