Article
HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa.
Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2017
Kityo Cissy, Thompson Jennifer, Nankya Immaculate, Hoppe Anne, Ndashimye Emmanuel, Warambwa Colin, Mambule Ivan, van Oosterhout Joep J, Wools-Kaloustian Kara, Bertagnolio Silvia, Easterbrook Philippa J, Mugyenyi Peter, Walker A Sarah, Paton Nicholas I
Abstract excerpt
OBJECTIVE: To determine drug resistance mutation (DRM) patterns in a large cohort of patients failing nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line antiretroviral therapy regimens in programs without routine viral load (VL) monitoring and to examine intersubtype differences in DRMs. DESIGN: Sequences from 787 adults/adolescents who failed an NNRTI-based first-line regimen in 13 clinics in...
Topics
- Adult
- Africa South of the Sahara
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Drug Resistance, Viral
- Female
- HIV Infections
- HIV Reverse Transcriptase