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Polymorphisms in MicroRNA Genes And Genes Involving in NMDAR Signaling and Schizophrenia: A Case-Control Study in Chinese Han Population.

Scientific reports - 10 Aug 2015

Zhang Yanxia, Fan Mei, Wang Qingzhong, He Guang, Fu Yingmei, Li Huafang, Yu Shunying

Abstract excerpt

Disturbances in glutamate signaling caused by disruption of N-methyl-D-aspartate-type glutamate receptor (NMDAR) have been implicated in schizophrenia. Findings suggested that miR-219, miR-132 and miR-107 could involve in NMDAR signaling by influencing the expression of pathway genes or the signaling transmission and single nucleotide polymorphisms (SNPs) within miRNA genes or miRNA target sites could result in...

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PMID: 26257337
DOI: 10.1038/srep12984
PMCID: PMC4530343

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