Back to search

Article

miR-146a and miR-200b alter cognition by targeting NMDA receptor subunits

2022-07-12

Abstract excerpt

MicroRNAs (miRNAs) play pivotal roles in fine-tuning gene regulation. Understanding the mechanism of action of such miRNAs might help in manipulating the respective pathways thus providing therapeutic options. We have investigated the physiological roles of two miRNAs, miR-146a and miR-200b, that are differentially expressed in neurological disorders such as Alzheimer’s disease andschizophrenia.We specifically stu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c11a04a5-2b50-512c-b937-57e05ab60f73
DOI
10.1101/2022.07.11.499553
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
miR-146a and miR-200b alter cognition by targeting NMDA receptor subunitsDOI 10.1101/2022.07.11.499553
Polymorphisms in MicroRNA Genes And Genes Involving in NMDAR Signaling and Schizophrenia: A Case-Control Study in Chinese Han Population.Semantic proximity
NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease ModelsSemantic proximity
microRNAs in CNS disorders.Semantic proximity
GRIN2A-related epilepsy and speech disorders: A comprehensive overview with a focus on the role of precision therapeutics.Semantic proximity
Relationships between plasma expression levels of microRNA-146a and microRNA-132 in epileptic patients and their cognitive, mental and psychological disordersSemantic proximity
MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1Semantic proximity
Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis.Semantic proximity
A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsySemantic proximity
MicroRNA-502-3p modulates the GABA A subunits, synaptic proteins and mitochondrial morphology in hippocampal neuronsSemantic proximity
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.Semantic proximity
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.Semantic proximity
Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative DiseasesSemantic proximity
Select a neighboring publication to make it the new centre.