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Article

The Role of RUNX2 in Osteosarcoma Oncogenesis

9 Dec 2010

Abstract excerpt

Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 "platform protein" in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that regulate the expression of multiple genes involved in...

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Identifiers

PMID: 21197465
DOI: 10.1155/2011/282745

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