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Article

Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.

Journal of vascular surgery - 1 Oct 2016

McClung Joseph M, McCord Timothy J, Southerland Kevin, Schmidt Cameron A, Padgett Michael E, Ryan Terence E, Kontos Christopher D

Abstract excerpt

OBJECTIVE: The primary preclinical model of peripheral artery disease, which involves acute limb ischemia (ALI), can result in appreciable muscle injury that is attributed to the acuity of the ischemic injury. A less acute model of murine limb ischemia using ameroid constrictors (ACs) has been developed in an attempt to mimic the chronic nature of human disease. However, there is currently little understanding of...

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Source

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Identifiers

PMID: 26254821
DOI: 10.1016/j.jvs.2015.06.139
PMCID: PMC4744137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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