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Article

Simultaneous measurement of passage through the restriction point and MCM loading in single cells

6 Aug 2015

Abstract excerpt

Passage through the Retinoblastoma protein (RB1)-dependent restriction point and the loading of minichromosome maintenance proteins (MCMs) are two crucial events in G1-phase that help maintain genome integrity. Deregulation of these processes can cause uncontrolled proliferation and cancer development. Both events have been extensively characterized individually, but their relative timing and inter-dependence...

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PMID: 26250117
DOI: 10.1093/nar/gkv744

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